Faculty dinner

Welcome and introduction
Eytan Stein & Courtney DiNardo

Session 1: History of differentiation syndrome
Chairs: TBC & TBC

• Reflections on the initial recognition of differentiation syndrome with ATRA: TBC
• History of differentiation syndrome recognition with ATRA and arsenic trioxide in Europe and European trials: TBC

Panel discussion

Session 2: Biology and pathogenesis of differentiation syndrome
Chairs: TBC & TBC

• What are the pathogenetic mechanisms that cause differentiation syndrome?: Stéphane De Botton
• How can we develop biomarkers for differentiation syndrome?: TBC
• How to design clinical and translational studies to identify the underlying mechanisms of DS better: TBC

Panel discussion

Break

 

Session 3: Clinical manifestations of differentiation syndrome
Chairs: TBC & TBC

• Differentiation syndrome in APL with ATRA/arsenic: TBC
• Differentiation syndrome with IDH inhibitors: Amir Fathi
• Differentiation syndrome with menin inhibitors: Eunice Wang
• Is there differentiation syndrome with other agents for AML? (BRG/BRM, FLT3, HMA): Alexander Perl
• Are there differences in the clinical manifestations of differentiation syndrome between differentiation agents/different subtypes of AML?: Ghayas Issa

Panel discussion

 

Lunch

Session 4: Treatment of differentiation syndrome
Chairs: TBC & TBC

• Are steroids the best way to treat active differentiation syndrome?: TBC
• Novel agents in the treatment of differentiation syndrome: TBC
• Should we create a standardized diagnostic criteria/algorithm for DS?: TBC
• Regulatory thoughts on differentiation syndrome: TBC

Panel discussion

Session 5: Prevention of differentiation syndrome
Chairs: TBC & TBC

• History of using steroid prophylaxis for APL: TBC
• What can we learn from steroid prophylaxis to prevent DS in APL?: Joshua Zeidner

Panel discussion

Break

 

Session 6: Future directions and items for investigation
Chairs: Eytan Stein & Courtney DiNardo

• Interactive group discussion

Panel discussion

 

Meeting conclusions & close
Eytan Stein & Courtney DiNardo