Faculty dinner

Welcome and introduction
Eytan Stein & Courtney DiNardo

Session 1: History of differentiation syndrome
Chairs: Hartmut Döhner & Ghayas Issa

• Reflections on the initial recognition of differentiation syndrome with ATRA: TBC
• History of differentiation syndrome recognition with ATRA and arsenic trioxide in Europe and European trials: Miguel Sanz

Panel discussion

Session 2: Biology and pathogenesis of differentiation syndrome
Chairs: TBC & TBC

• What are the pathogenetic mechanisms that cause differentiation syndrome?: Stéphane De Botton
• How can we develop biomarkers for differentiation syndrome?: Kai Chin
• How to design clinical and translational studies to identify the underlying mechanisms of DS better: Alice Mims

Panel discussion

Break

 

Session 3: Clinical manifestations of differentiation syndrome
Chairs: Jessica Altman & Joshua Zeidner

• Differentiation syndrome in APL with ATRA/arsenic: Martin Tallman
• A double-edged sword? Differentiation syndrome and IDH inhibitors: Amir Fathi
• Differentiation syndrome with menin inhibitors: Eunice Wang
• Is there differentiation syndrome with other agents for AML? (BRG/BRM, FLT3, HMA): Alexander Perl
• Are there differences in the clinical manifestations of differentiation syndrome between differentiation agents/different subtypes of AML?: Ghayas Issa

Panel discussion

 

Lunch

Session 4: Treatment of differentiation syndrome
Chairs: Amir Fathi & Eunice Wang

• Are steroids the best way to treat active differentiation syndrome?: Justin Watts
• Novel agents in the treatment of differentiation syndrome: Yannis Valtis
• Should we create a standardized diagnostic criteria/algorithm for DS?: Jessica Altman
• Regulatory thoughts on differentiation syndrome: TBC
• Industry research update: TBC

Panel discussion

Session 5: Prevention of differentiation syndrome
Chairs: TBC & TBC

• History of using steroid prophylaxis for APL: Yasmin Abaza
• What can we learn from steroid prophylaxis to prevent DS in APL?: Joshua Zeidner

Panel discussion

Break

 

Session 6: Future directions and items for investigation
Chairs: Eytan Stein & Courtney DiNardo

• Interactive group discussion

Panel discussion

 

Meeting conclusions & close
Eytan Stein & Courtney DiNardo